pentobarbital will lower the extent or influence of fosamprenavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital improves effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Monitor. Coadministration of ifosfamide with CYP2B6 inducers may raise metabolism of ifosfamide to its metabolite. Check for greater effects/toxicities if combined with CYP2B6 inducers.
With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.
This drug may enhance the metabolism of estradiol when administered concurrently; individuals on oral contraceptives are becoming pregnant when concurrently dealt with with antiepileptic drugs; suggest an alternate contraceptive technique to Ladies using this drug
pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration with strong CYP3A4 inducers; these drugs reduce exposure to vandetanib by approximately 40%.
pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Energetic alkylating metabolites.
Possibly improves toxicity of the other by pharmacodynamic synergism. Steer clear of or Use Alternate Drug. Profound sedation, respiratory melancholy, coma, and Dying may well outcome if coadministered. Reserve concomitant prescribing of such drugs in clients for whom other procedure solutions are inadequate. Restrict dosages and durations for the least required. Keep an eye on intently for signs of respiratory despair and sedation.
pentobarbital will lessen the extent or effect of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will minimize the level or impact of piroxicam by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Mysterious.
This drug may possibly interfere with the absorption of orally administered griseofulvin, decreasing its blood degrees; effects read more of blood stage reduction unfamiliar; preferable in order to avoid concomitant administration of these drugs
pentobarbital will lessen the level or influence of cinacalcet by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the extent or effect of paclitaxel protein sure by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
pentobarbital will lower the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the extent or influence of eltrombopag by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep an eye on.